Data/hora: 09/06/2024 13:36:35

Provedor de dados: | 56
País: | Brazil
Título: | Immunomodulatory effect of mesenchymal stem cells
Autores: | Herrero,C.; Pérez-Simón,J.A.
Data: | 2010-05-01
Ano: | 2010
Palavras-chave: | Mesenchymal stem cells; T-lymphocytes; B-lymphocytes; Dendritic cells; Graft-versus-host disease; Allogeneic transplanta.
Resumo: | Mesenchymal stem cells (MSC) are multipotential nonhematopoietic progenitor cells capable of differentiating into multiple mesenchymal tissues. MSC are able to reconstitute the functional human hematopoietic microenvironment and promote engraftment of hematopoietic stem cells. MSC constitutively express low levels of major histocompatibility complex-I molecules and do not express costimulatory molecules such as CD80, CD86 or CD40, thus lacking immunogenicity. Furthermore, they are able to suppress T- and B-lymphocyte activation and proliferation and may also affect dendritic cell maturation. Based on these properties, MSC are being used in regenerative medicine and also for the treatment of autoimmune diseases and graft-versus-host disease. On the other hand, MSC from patients diagnosed with myelodysplastic syndromes or multiple myeloma display abnormalities, which could play a role in the physiopathology of the disease. Finally, in patients with immune thrombocytopenic purpura, MSC have a reduced proliferative capacity and a lower inhibitory effect on T-cell proliferation compared with MSC from healthy donors.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000500002
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2010007500033
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.43 n.5 2010
Fonte: | info:eu-repo/semantics/openAccess