Data/hora: 01/06/2024 11:26:17

Provedor de dados: | 56
País: | Brazil
Título: | Duration-controlled swimming exercise training induces cardiac hypertrophy in mice
Autores: | Evangelista,F.S.; Brum,P.C.; Krieger,J.E.
Data: | 2003-12-01
Ano: | 2003
Palavras-chave: | Exercise training; Swimming; Cardiac hypertrophy; Mice; Myocardium.
Resumo: | Exercise training associated with robust conditioning can be useful for the study of molecular mechanisms underlying exercise-induced cardiac hypertrophy. A swimming apparatus is described to control training regimens in terms of duration, load, and frequency of exercise. Mice were submitted to 60- vs 90-min session/day, once vs twice a day, with 2 or 4% of the weight of the mouse or no workload attached to the tail, for 4 vs 6 weeks of exercise training. Blood pressure was unchanged in all groups while resting heart rate decreased in the trained groups (8-18%). Skeletal muscle citrate synthase activity, measured spectrophotometrically, increased (45-58%) only as a result of duration and frequency-controlled exercise training, indicating that endurance conditioning was obtained. In groups which received duration and endurance conditioning, cardiac weight (14-25%) and myocyte dimension (13-20%) increased. The best conditioning protocol to promote physiological hypertrophy, our primary goal in the present study, was 90 min, twice a day, 5 days a week for 4 weeks with no overload attached to the body. Thus, duration- and frequency-controlled exercise training in mice induces a significant conditioning response qualitatively similar to that observed in humans.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003001200018
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2003001200018
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.36 n.12 2003
Fonte: | info:eu-repo/semantics/openAccess