Data/hora: 07/06/2024 09:19:51

Provedor de dados: | 56
País: | Brazil
Título: | Cellular and matrix interactions during the development of T lymphocytes
Autores: | Owen,J.J.T.; McLoughlin,D.E.; Suniara,R.K.; Jenkinson,E.J.
Data: | 1999-05-01
Ano: | 1999
Palavras-chave: | Extracellular matrix; Epithelial cells; Fibroblasts; Integrins; Interleukin-7; Thymus.
Resumo: | The thymus contains an extensive extracellular matrix. Although thymocytes express integrins capable of binding to matrix molecules, the functional significance of the matrix for T cell development is uncertain. We have shown that the matrix is associated with thymic fibroblasts which are required for the CD44+ CD25+ stage of double negative (CD4-8-) thymocyte development. The survival of cells at this stage is dependent on IL-7 and we propose that the role of fibroblasts is to present, via the matrix, IL-7 to developing T cells.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000500008
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X1999000500008
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.32 n.5 1999
Fonte: | info:eu-repo/semantics/openAccess