Data/hora: 09/06/2024 11:31:15

Provedor de dados: 	56	
País: 	Brazil	
Título: 	Cellular and matrix interactions during the development of T lymphocytes	
Autores: 	Owen,J.J.T.; McLoughlin,D.E.; Suniara,R.K.; Jenkinson,E.J.	
Data: 	1999-05-01	
Ano: 	1999	
Palavras-chave: 	Extracellular matrix; Epithelial cells; Fibroblasts; Integrins; Interleukin-7; Thymus.	
Resumo: 	The thymus contains an extensive extracellular matrix. Although thymocytes express integrins capable of binding to matrix molecules, the functional significance of the matrix for T cell development is uncertain. We have shown that the matrix is associated with thymic fibroblasts which are required for the CD44+ CD25+ stage of double negative (CD4-8-) thymocyte development. The survival of cells at this stage is dependent on IL-7 and we propose that the role of fibroblasts is to present, via the matrix, IL-7 to developing T cells.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000500008	
Editor: 	Associação Brasileira de Divulgação Científica	
Relação: 	10.1590/S0100-879X1999000500008	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Medical and Biological Research  v.32 n.5 1999	
Fonte: 	info:eu-repo/semantics/openAccess