Data/hora: 01/06/2024 02:27:59

Provedor de dados: 	56	
País: 	Brazil	
Título: 	Effect of cocaine on periadolescent rats with or without early maternal separation	
Autores: 	Planeta,C.S.; Marin,M.T.	
Data: 	2002-11-01	
Ano: 	2002	
Palavras-chave: 	Cocaine; Adolescence; Behavioral sensitization; Maternal separation; Early stress.	
Resumo: 	Cocaine-induced behavioral sensitization and weight loss were investigated in periadolescent Wistar rats kept with their mothers or subjected to repeated maternal separation. Litters allocated to the separation procedure were placed in a temperature-controlled (33ºC) chamber for 3 h per day from postnatal day 6 (P6) to P20. Non-handled rats were left undisturbed until weaning. Treatments were started on P30-31 and the test was performed on P36-37. Animals received injections of saline or cocaine (10 mg/kg, sc) twice daily for 5 days. On day 6 all animals received saline. On day 7 animals were challenged with 10 mg/kg cocaine and their locomotion was evaluated in activity cages. A third group received saline throughout the 7-day period. Body weights were recorded on P30-31 and P36-37. Two-way ANOVA on body weights showed a main effect of treatment group (F(1,35) = 10.446, P = 0.003; N = 10-12). Non-handled rats treated with cocaine for 5 days gained significantly less weight, while no significant effect was observed in maternally separated rats. Two-way ANOVA revealed a main effect of drug treatment on locomotor activity (F(2,32) = 15.209, P&lt;0.001; N = 6-8), but not on rearing condition (F(1,32)&lt;0.001, P = 0.998). Animals pretreated with cocaine showed a clear behavioral sensitization relative to the saline group. No difference in the magnitude of sensitization was found between separated and non-handled animals. Only the effect of cocaine on weight gain was significantly affected by repeated episodes of early maternal separation during the pre-weaning period.	
Tipo: 	Info:eu-repo/semantics/other	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001100015	
Editor: 	Associação Brasileira de Divulgação Científica	
Relação: 	10.1590/S0100-879X2002001100015	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Medical and Biological Research  v.35 n.11 2002	
Fonte: 	info:eu-repo/semantics/openAccess