Data/hora: 12/06/2024 10:53:20

Provedor de dados: 	56	
País: 	Brazil	
Título: 	Longitudinal brain volumetric changes during one year in non-elderly healthy adults: a voxel-based morphometry study	
Autores: 	Guimarães,R.M.; Schaufelberger,M.S.; Santos,L.C.; Duran,F.L.S.; Menezes,P.R.; Scazufca,M.; Gouvea,M.T.V; Busatto,G.F.	
Data: 	2012-06-01	
Ano: 	2012	
Palavras-chave: 	Gray matter; Aging; Voxel-based morphometry; Magnetic resonance imaging; Prefrontal cortex; Hippocampus.	
Resumo: 	Previous cross-sectional magnetic resonance imaging (MRI) studies of healthy aging in young adults have indicated the presence of significant inverse correlations between age and gray matter volumes, although not homogeneously across all brain regions. However, such cross-sectional studies have important limitations and there is a scarcity of detailed longitudinal MRI studies with repeated measures obtained in the same individuals in order to investigate regional gray matter changes during short periods of time in non-elderly healthy adults. In the present study, 52 healthy young adults aged 18 to 50 years (27 males and 25 females) were followed with repeated MRI acquisitions over approximately 15 months. Gray matter volumes were compared between the two times using voxel-based morphometry, with the prediction that volume changes would be detectable in the frontal lobe, temporal neocortex and hippocampus. Voxel-wise analyses showed significant (P &lt; 0.05, family-wise error corrected) relative volume reductions of gray matter in two small foci located in the right orbitofrontal cortex and left hippocampus. Separate comparisons for males and females showed bilateral gray matter relative reductions in the orbitofrontal cortex over time only in males. We conclude that, in non-elderly healthy adults, subtle gray matter volume alterations are detectable after short periods of time. This underscores the dynamic nature of gray matter changes in the brain during adult life, with regional volume reductions being detectable in brain regions that are relevant to cognitive and emotional processes.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000600007	
Editor: 	Associação Brasileira de Divulgação Científica	
Relação: 	10.1590/S0100-879X2012007500046	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Medical and Biological Research  v.45 n.6 2012	
Fonte: 	info:eu-repo/semantics/openAccess