Data/hora: 05/06/2024 17:03:37

Provedor de dados: | 56
País: | Brazil
Título: | Ethanol-induced hypothermia in rats is antagonized by dexamethasone
Data: | 1997-01-01
Ano: | 1997
Palavras-chave: | Ethanol; Dexamethasone; Hypothermia; Glucocorticoids; Rats.
Resumo: | The effect of dexamethasone on ethanol-induced hypothermia was investigated in 3.5-month old male Wistar rats (N = 10 animals per group). The animals were pretreated with dexamethasone (2.0 mg/kg, ip; volume of injection = 1 ml/kg) 15 min before ethanol administration (2.0, 3.0 and 4.0 g/kg, ip; 20% w/v) and the colon temperature was monitored with a digital thermometer 30, 60 and 90 min after ethanol administration. Ethanol treatment produced dose-dependent hypothermia throughout the experiment (-1.84 ± 0.10, -2.79 ± 0.09 and -3.79 ± 0.15oC for 2.0, 3.0 and 4.0 g/kg ethanol, respectively, 30 min after ethanol) but only the effects of 2.0 and 3.0 g/kg ethanol were significantly antagonized (-0.57 ± 0.09 and -1.25 ± 0.10, respectively, 30 min after ethanol) by pretreatment with dexamethasone (ANOVA, P&amp;lt;0.05). These results are in agreement with data from the literature on the rapid antagonism by glucocorticoids of other effects of ethanol. The antagonism was obtained after a short period of time, suggesting that the effect of dexamethasone is different from the classical actions of corticosteroids
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000100011
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X1997000100011
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.30 n.1 1997
Fonte: | info:eu-repo/semantics/openAccess