Data/hora: 06/06/2024 03:39:59

Provedor de dados: | 56
País: | Brazil
Título: | Biodistribution of 99m technetium- labeled creatinine in healthy rats
Autores: | Yilmaz,O.; Yurt Lambrecht,F.; Soylu,A.; Durkan,K.; Kavukcu,S.
Data: | 2007-06-01
Ano: | 2007
Palavras-chave: | Biodistribution; Creatinine; 99mTechnetium; 99mTc-creatinine; Rat.
Resumo: | The distribution of creatinine, one of the toxic guanidine compounds, in various tissues has not been studied in detail by using radiolabeled creatinine. Our objective was to investigate the biodistribution of creatinine labeled with 99m technetium (99mTc) by the stannous (II) chloride method in healthy male Wistar rats. Quality controls were carried out by radio thin layer chromatography, high-performance liquid chromatography, and paper electrophoresis. The labeling yield was 85 ± 2% under optimum conditions (pH 7 and 100 µg stannous chloride). Rats (N = 12) were injected intravenously with 99mTc-creatinine and their blood and visceral organs were evaluated for 99mTc-creatinine uptake as percent of the injected dose per gram wet weight of each tissue (%ID/g). The lowest amount of uptake was detected in the brain and testis. When the rate of uptake was evaluated, only the kidney showed increasing rates of uptake of 99mTc-creatinine throughout the study. Kidneys showed the highest amount of uptake throughout the study (P &lt; 0.001 compared to all other organs), followed by liver, spleen and lung tissue.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000600009
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2006005000111
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.40 n.6 2007
Fonte: | info:eu-repo/semantics/openAccess