Data/hora: 01/06/2024 07:39:58

Provedor de dados: | 56
País: | Brazil
Título: | A combination of methylprednisolone and quercetin is effective for the treatment of cardiac contusion following blunt chest trauma in rats
Autores: | Demir,F.; Güzel,A.; Katı,C.; Karadeniz,C.; Akdemir,U.; Okuyucu,A.; Gacar,A.; Özdemir,S.; Güvenç,T.
Data: | 2014-09-01
Ano: | 2014
Palavras-chave: | Blunt chest trauma; Cardiac contusion; Quercetin; Methylprednisolone; INOS.
Resumo: | Cardiac contusion is a potentially fatal complication of blunt chest trauma. The effects of a combination of quercetin and methylprednisolone against trauma-induced cardiac contusion were studied. Thirty-five female Sprague-Dawley rats were divided into five groups (n=7) as follows: sham, cardiac contusion with no therapy, treated with methylprednisolone (30 mg/kg on the first day, and 3 mg/kg on the following days), treated with quercetin (50 mg·kg−1·day−1), and treated with a combination of methylprednisolone and quercetin. Serum troponin I (Tn-I) and tumor necrosis factor-alpha (TNF-α) levels and cardiac histopathological findings were evaluated. Tn-I and TNF-α levels were elevated after contusion (P=0.001 and P=0.001). Seven days later, Tn-I and TNF-α levels decreased in the rats treated with methylprednisolone, quercetin, and the combination of methylprednisolone and quercetin compared to the rats without therapy, but a statistical significance was found only with the combination therapy (P=0.001 and P=0.011, respectively). Histopathological degeneration and necrosis scores were statistically lower in the methylprednisolone and quercetin combination group compared to the group treated only with methylprednisolone (P=0.017 and P=0.007, respectively). However, only degeneration scores were lower in the combination therapy group compared to the group treated only with quercetin (P=0.017). Inducible nitric oxide synthase positivity scores were decreased in all treatment groups compared to the untreated groups (P=0.097, P=0.026, and P=0.004, respectively). We conclude that a combination of quercetin and methylprednisolone can be used for the specific treatment of cardiac contusion.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000900766
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/1414-431X20144021
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.47 n.9 2014
Fonte: | info:eu-repo/semantics/openAccess