Data/hora: 07/06/2024 10:26:24

Provedor de dados: | 56
País: | Brazil
Título: | Review of the Y chromosome and hypertension
Autores: | Ely,D.; Turner,M.; Milsted,A.
Data: | 2000-06-01
Ano: | 2000
Palavras-chave: | Sympathetic nervous system; Testosterone; Androgen receptor; Collagen.
Resumo: | The Y chromosome from spontaneously hypertensive rats (SHR) has a locus that raises blood pressure 20-25 mmHg. Associated with the SHR Y chromosome effect is a 4-week earlier pubertal rise of testosterone and dependence upon the androgen receptor for the full blood pressure effect. Several indices of enhanced sympathetic nervous system (SNS) activity are also associated with the SHR Y chromosome. Blockade of SNS outflow reduced the blood pressure effect. Salt sensitivity was increased by the Y chromosome as was salt appetite which was SNS dependent. A strong correlation (r = 0.57, P&amp;lt;0.001) was demonstrable between plasma testosterone and angiotensin II. Coronary collagen increased with blood pressure and the presence of the SHR Y chromosome. A promising candidate gene for the Y effect is the Sry locus (testis determining factor), a transcription factor which may also have other functions.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000600009
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2000000600009
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.33 n.6 2000
Fonte: | info:eu-repo/semantics/openAccess