Data/hora: 13/06/2024 03:51:15

Provedor de dados: | 56
País: | Brazil
Título: | Different levels of brain-derived neurotrophic factor and cortisol in healthy heavy smokers
Autores: | Neves,C.D.C.; Lacerda,A.C.R.; Lima,L.P.; Lage,V.K.S.; Balthazar,C.H.; Leite,H.R.; Mendonça,V.A.
Data: | 2017-01-01
Ano: | 2017
Palavras-chave: | BDNF; Nicotine consumption; HPA axis; Addiction; Reward system.
Resumo: | Studies suggest that brain-derived neurotrophic factor (BDNF) and the hypothalamic-pituitary-adrenal (HPA) axis modulate dopaminergic activity in response to nicotine and that the concentrations of BDNF and cortisol seem to be dependent on the amount and duration of smoking. Therefore, we investigated BDNF and cortisol levels in smokers ranked by daily cigarette consumption. Twenty-seven adult males (13 non-smokers and 14 smokers) participated in the study. The smokers were divided in two groups: light (n=7) and heavy smokers (n=7). Anthropometric parameters and age were paired between the groups, and plasma BDNF and salivary cortisol levels were measured. Saliva samples were collected on awakening, 30 min after awakening, at 10:00 and 12:00 am, 5:00 and 10:00 pm. Additionally, cotinine serum levels were measured in smokers. Heavy smokers had higher mean values of BDNF compared to the control group (P=0.01), whereas no difference was observed in light smokers. Moreover, heavy smokers presented lower cortisol levels in the last collection (10:00 pm) than the control group (P=0.02) and presented statically higher values of cotinine than the light smokers (P=0.002). In conclusion, changes in BDNF and cortisol levels (10:00 pm) appear to be dependent on heavy cigarette smoking and can be involved in activation and in the relationship between the mesolimbic system and the HPA axis.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001200608
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/1414-431x20176424
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.50 n.12 2017
Fonte: | info:eu-repo/semantics/openAccess