Data/hora: 01/06/2024 09:25:58

Provedor de dados: 	56	
País: 	Brazil	
Título: 	Importance of hyaluronan biosynthesis and degradation in cell differentiation and tumor formation	
Autores: 	Heldin,P.	
Data: 	2003-08-01	
Ano: 	2003	
Palavras-chave: 	Hyaluronan; Synthase; Hyaluronidase; Tumor invasion; Extracellular matrix; Pericellular matrix.	
Resumo: 	Hyaluronan is an important connective tissue glycosaminoglycan. Elevated hyaluronan biosynthesis is a common feature during tissue remodeling under both physiological and pathological conditions. Through its interactions with hyaladherins, hyaluronan affects several cellular functions such as cell migration and differentiation. The activities of hyaluronan-synthesizing and -degrading enzymes have been shown to be regulated in response to growth factors. During tumor progression hyaluronan stimulates tumor cell growth and invasiveness. Thus, elucidation of the molecular mechanisms which regulate the activities of hyaluronan-synthesizing and -degrading enzymes during tumor progression is highly desired.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000800002	
Editor: 	Associação Brasileira de Divulgação Científica	
Relação: 	10.1590/S0100-879X2003000800002	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Medical and Biological Research  v.36 n.8 2003	
Fonte: 	info:eu-repo/semantics/openAccess