Data/hora: 06/06/2024 03:47:19

Provedor de dados: 	56	
País: 	Brazil	
Título: 	Role of Th1 and Th2 cells in autoimmune demyelinating disease	
Autores: 	Nagelkerken,L.	
Data: 	1998-01-01	
Ano: 	1998	
Palavras-chave: 	Multiple sclerosis; Experimental allergic encephalomyelitis; Cytokines; Glucocorticoids; Th1 cells; Antigen-presenting cells.	
Resumo: 	Evidence is accumulating that Th1 cells play an important role in the development of multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE), whereas Th2 cells contribute to recovery from disease. A major determinant in the development of Th1 and Th2 cells is the type of antigen-presenting cell (APC) involved and its functional characteristics, e.g., the production of interleukin-12. Therefore, modulation of APC might interfere with the development of Th1 type responses and as such be beneficial for MS and EAE. The potential of cytokines, in particular interleukin-10, and glucocorticoids to exert a selective effect on APC, and as a consequence to affect the Th1-Th2 balance in EAE, is discussed	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100007	
Editor: 	Associação Brasileira de Divulgação Científica	
Relação: 	10.1590/S0100-879X1998000100007	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Medical and Biological Research  v.31 n.1 1998	
Fonte: 	info:eu-repo/semantics/openAccess