Data/hora: 05/06/2024 07:37:05

Provedor de dados: | 56
País: | Brazil
Título: | Interleukin-5 and interleukin-10 are major cytokines in cerebrospinal fluid from patients with active neurocysticercosis
Autores: | Rodrigues Jr.,V.; de-Mello,F.A.; Magalhães,E.P.; Ribeiro,S.B.F.; Marquez,J.O.
Data: | 2000-09-01
Ano: | 2000
Palavras-chave: | Cysticercosis; Cytokines; Cerebrospinal fluid.
Resumo: | Neurocysticercosis (NCC) is a common neurological disorder especially in developing countries, caused by infection of the brain with encysted larvae of the tapeworm Taenia solium. Seizures are a common finding associated with this disease. The objective of the present study was to evaluate the correlation between the levels of various cytokines present in the cerebrospinal fluid (CSF) of patients with NCC and the severity of the disease. The levels of the cytokines IL-1ß, TNF-alpha, IL-5, IL-10 and IFN-gamma were determined in the CSF of 22 patients with active NCC, 13 patients with inactive NCC and 15 control subjects. CSF from patients with active NCC presented significantly higher IL-5 levels compared to control subjects. IL-5 and IL-10 levels in CSF from NCC patients with inflammatory CSF were significantly higher than those detected in non-inflammatory CSF. These results show a predominant Th2 lymphocyte activation in human NCC and also indicate the possible use of cytokines in the CSF as a marker for the differential diagnosis between inactive disease and the active form of NCC.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000900011
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2000000900011
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.33 n.9 2000
Fonte: | info:eu-repo/semantics/openAccess