Data/hora: 12/06/2024 10:32:34

Provedor de dados: | 56
País: | Brazil
Título: | The prima donna of epigenetics: the regulation of gene expression by DNA methylation
Autores: | Santos,K.F.; Mazzola,T.N.; Carvalho,H.F.
Data: | 2005-10-01
Ano: | 2005
Palavras-chave: | Epigenetics; DNA methylation; Inheritable changes in gene expression; Transgenerational carcinogenesis; Environmental influence on memory formation.
Resumo: | This review focuses on the mechanisms of DNA methylation, DNA methylation pattern formation and their involvement in gene regulation. Association of DNA methylation with imprinting, embryonic development and human diseases is discussed. Furthermore, besides considering changes in DNA methylation as mechanisms of disease, the role of epigenetics in general and DNA methylation in particular in transgenerational carcinogenesis, in memory formation and behavior establishment are brought about as mechanisms based on the cellular memory of gene expression patterns.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001000010
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2005001000010
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.38 n.10 2005
Fonte: | info:eu-repo/semantics/openAccess