Data/hora: 06/06/2024 06:15:10

Provedor de dados: 	56	
País: 	Brazil	
Título: 	Cytokines in innate and acquired immunity to Trypanosoma cruzi infection	
Autores: 	Abrahamsohn,I.A.	
Data: 	1998-01-01	
Ano: 	1998	
Palavras-chave: 	Trypanosoma cruzi; Interferon-gamma; Interleukin-12; TNF-alpha; Interleukin-10; Innate immunity; Knock-out mice.	
Resumo: 	Resistance to Trypanosoma cruzi infections is critically dependent on cytokine-mediated activation of cell-mediated immune effector mechanisms. This review focuses on the role of IL-10, TNF-&lt;FONT FACE="Symbol"&gt;a&lt;/font&gt;, IFN-&lt;FONT FACE="Symbol"&gt;g&lt;/font&gt; and IL-12 in controlling T. cruzi replication by the innate and specific immune systems of the vertebrate host. A study performed on mice with disrupted recombinase-activating genes (RAG/KO), which lack T and B lymphocytes, revealed the importance of IL-12, IFN-&lt;FONT FACE="Symbol"&gt;g&lt;/font&gt; and TNF-&lt;FONT FACE="Symbol"&gt;a&lt;/font&gt; in the resistance against T. cruzi mediated by the innate immune system. In addition, data from experiments using IL-10 KO, RAG/KO and double RAG/IL-10 KO mice indicating an in vivo regulatory role of IL-10 in innate and T. cruzi-specific immunity are discussed	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100015	
Editor: 	Associação Brasileira de Divulgação Científica	
Relação: 	10.1590/S0100-879X1998000100015	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Medical and Biological Research  v.31 n.1 1998	
Fonte: 	info:eu-repo/semantics/openAccess