Data/hora: 10/06/2024 02:16:46

Provedor de dados: | 56
País: | Brazil
Título: | Rosmarinus officinalis L. increases Caenorhabditis elegans stress resistance and longevity in a DAF-16, HSF-1 and SKN-1-dependent manner
Autores: | Zamberlan,D.C.; Amaral,G.P.; Arantes,L.P.; Machado,M.L.; Mizdal,C.R.; Campos,M.M.A.; Soares,F.A.A.
Data: | 2016-01-01
Ano: | 2016
Palavras-chave: | Caenorhabditis elegans; Natural compounds; Rosemary; Daf-2; Stress resistance; Aging.
Resumo: | Improving overall health and quality of life, preventing diseases and increasing life expectancy are key concerns in the field of public health. The search for antioxidants that can inhibit oxidative damage in cells has received a lot of attention. Rosmarinus officinalis L. represents an exceptionally rich source of bioactive compounds with pharmacological properties. In the present study, we explored the effects of the ethanolic extract of R. officinalis (eeRo) on stress resistance and longevity using the non-parasitic nematode Caenorhabditis elegans as a model. We report for the first time that eeRo increased resistance against oxidative and thermal stress and extended C. elegans longevity in an insulin/IGF signaling pathway-dependent manner. These data emphasize the eeRo beneficial effects on C. elegans under stress.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000900601
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/1414-431x20165235
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.49 n.9 2016
Fonte: | info:eu-repo/semantics/openAccess