Data/hora: 06/06/2024 01:19:31

Provedor de dados: | 56
País: | Brazil
Título: | The role of CD8+ T cells during allograft rejection
Autores: | Bueno,V.; Pestana,J.O.M.
Data: | 2002-11-01
Ano: | 2002
Palavras-chave: | Transplantation; Rejection; T cells; Cytokines; Chemokines.
Resumo: | Organ transplantation can be considered as replacement therapy for patients with end-stage organ failure. The percent of one-year allograft survival has increased due, among other factors, to a better understanding of the rejection process and new immunosuppressive drugs. Immunosuppressive therapy used in transplantation prevents activation and proliferation of alloreactive T lymphocytes, although not fully preventing chronic rejection. Recognition by recipient T cells of alloantigens expressed by donor tissues initiates immune destruction of allogeneic transplants. However, there is controversy concerning the relative contribution of CD4+ and CD8+ T cells to allograft rejection. Some animal models indicate that there is an absolute requirement for CD4+ T cells in allogeneic rejection, whereas in others CD4-depleted mice reject certain types of allografts. Moreover, there is evidence that CD8+ T cells are more resistant to immunotherapy and tolerance induction protocols. An intense focal infiltration of mainly CD8+CTLA4+ T lymphocytes during kidney rejection has been described in patients. This suggests that CD8+ T cells could escape from immunosuppression and participate in the rejection process. Our group is primarily interested in the immune mechanisms involved in allograft rejection. Thus, we believe that a better understanding of the role of CD8+ T cells in allograft rejection could indicate new targets for immunotherapy in transplantation. Therefore, the objective of the present review was to focus on the role of the CD8+ T cell population in the rejection of allogeneic tissue.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001100001
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2002001100001
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.35 n.11 2002
Fonte: | info:eu-repo/semantics/openAccess