Data/hora: 05/06/2024 10:11:34

Provedor de dados: | 56
País: | Brazil
Título: | RNA and DNA aptamers as potential tools to prevent cell adhesion in disease
Autores: | Ulrich,H.; Alves,M.J.M.; Colli,W.
Data: | 2001-03-01
Ano: | 2001
Palavras-chave: | SELEX; Aptamers; Cell adhesion; Cell invasion; Trypanosoma cruzi.
Resumo: | Recent research has shown that receptor-ligand interactions between surfaces of communicating cells are necessary prerequisites for cell proliferation, cell differentiation and immune defense. Cell-adhesion events have also been proposed for pathological conditions such as cancer growth, metastasis, and host-cell invasion by parasites such as Trypanosoma cruzi. RNA and DNA aptamers (aptus = Latin, fit) that have been selected from combinatorial nucleic acid libraries are capable of binding to cell-adhesion receptors leading to a halt in cellular processes induced by outside signals as a consequence of blockage of receptor-ligand interactions. We outline here a novel approach using RNA aptamers that bind to T. cruzi receptors and interrupt host-cell invasion in analogy to existing procedures of blocking selectin adhesion and function in vitro and in vivo.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000300002
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2001000300002
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.34 n.3 2001
Fonte: | info:eu-repo/semantics/openAccess