Data/hora: 11/06/2024 11:57:36

Provedor de dados: 	56	
País: 	Brazil	
Título: 	Age-related changes of the multidrug resistance P-glycoprotein function in normal human peripheral blood T lymphocytes	
Autores: 	Machado,C.G.; Calado,R.T.; Garcia,A.B.; Falcão,R.P.	
Data: 	2003-12-01	
Ano: 	2003	
Palavras-chave: 	P-glycoprotein; Multidrug resistance; Lymphocytes; Rhodamine 123; Flow cytometry.	
Resumo: 	The multidrug resistance P-glycoprotein is a transmembrane efflux pump expressed by lymphocytes and is involved in their cytolytic activity. In the present study, we investigated the age-related changes of P-glycoprotein function in normal peripheral blood lymphocytes. Blood samples from 90 normal volunteers (age range, 0 to 86 years) were analyzed. P-glycoprotein function was assessed by the flow cytometric rhodamine 123 assay. P-glycoprotein function was highest in cord blood and progressively declined with age in peripheral blood T CD4+ and CD8+ cells. In contrast, P-glycoprotein function did not vary with age in CD19+ B or CD16+CD56+ natural killer cells. These data suggest that the decline in P-glycoprotein function in T CD4+ and CD8+ lymphocytes as a function of age may contribute to the decrease in T cell cytolytic activity with aging.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003001200006	
Editor: 	Associação Brasileira de Divulgação Científica	
Relação: 	10.1590/S0100-879X2003001200006	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Medical and Biological Research  v.36 n.12 2003	
Fonte: 	info:eu-repo/semantics/openAccess