Data/hora: 06/06/2024 04:42:58

Provedor de dados: | 56
País: | Brazil
Título: | Age-related changes of the multidrug resistance P-glycoprotein function in normal human peripheral blood T lymphocytes
Autores: | Machado,C.G.; Calado,R.T.; Garcia,A.B.; Falcão,R.P.
Data: | 2003-12-01
Ano: | 2003
Palavras-chave: | P-glycoprotein; Multidrug resistance; Lymphocytes; Rhodamine 123; Flow cytometry.
Resumo: | The multidrug resistance P-glycoprotein is a transmembrane efflux pump expressed by lymphocytes and is involved in their cytolytic activity. In the present study, we investigated the age-related changes of P-glycoprotein function in normal peripheral blood lymphocytes. Blood samples from 90 normal volunteers (age range, 0 to 86 years) were analyzed. P-glycoprotein function was assessed by the flow cytometric rhodamine 123 assay. P-glycoprotein function was highest in cord blood and progressively declined with age in peripheral blood T CD4+ and CD8+ cells. In contrast, P-glycoprotein function did not vary with age in CD19+ B or CD16+CD56+ natural killer cells. These data suggest that the decline in P-glycoprotein function in T CD4+ and CD8+ lymphocytes as a function of age may contribute to the decrease in T cell cytolytic activity with aging.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003001200006
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2003001200006
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.36 n.12 2003
Fonte: | info:eu-repo/semantics/openAccess