Data/hora: 01/06/2024 00:55:09

Provedor de dados: | 56
País: | Brazil
Título: | Umbilical cord blood and neonatal endothelin-1 levels in preterm newborns with and without respiratory distress syndrome
Autores: | Benjamin,A.C.W.; Silveira,R.C.; Procianoy,R.S.
Data: | 2005-09-01
Ano: | 2005
Palavras-chave: | Endothelin-1; Respiratory distress syndrome; Prematurity; Hyaline membrane disease; Pulmonary hypertension; SNAPPE II.
Resumo: | Increased pulmonary vascular resistance in preterm newborn infants with respiratory distress syndrome is suggested, and endothelin-1 plays an important role in pulmonary vascular reactivity in newborns. We determined umbilical cord blood and neonatal (second sample) levels of endothelin-1 in 18 preterm newborns with respiratory distress syndrome who had no clinical or echocardiographic diagnosis of pulmonary hypertension and 22 without respiratory distress syndrome (gestational ages: 31.4 ± 1.6 and 29.3 ± 2.3 weeks, respectively). Umbilical cord blood and a second blood sample taken 18 to 40 h after birth were used for endothelin-1 determination by enzyme immunoassay. Median umbilical cord blood endothelin-1 levels were similar in both groups (control: 10.9 and respiratory distress syndrome: 11.4 pg/mL) and were significantly higher than in the second sample (control: 1.7 pg/mL and respiratory distress syndrome: 3.5 pg/mL, P &lt; 0.001 for both groups). Median endothelin-1 levels in the second sample were significantly higher in children with respiratory distress syndrome than in control infants (P &lt; 0.001). There were significant positive correlations between second sample endothelin-1 and Score for Neonatal Acute Physiology and Perinatal Extension II (r = 0.36, P = 0.02), and duration of mechanical ventilation (r = 0.64, P = 0.02). A slower decline of endothelin-1 from birth to 40 h of life was observed in newborns with respiratory distress syndrome when compared to controls. A significant correlation between neonatal endothelin-1 levels and some illness-severity signs suggests that endothelin-1 plays a role in the natural course of respiratory distress syndrome in preterm newborns.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000900017
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2005000900017
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.38 n.9 2005
Fonte: | info:eu-repo/semantics/openAccess