Data/hora: 02/06/2024 13:13:42

Provedor de dados: | 56
País: | Brazil
Título: | Clearance-inducing antibodies are responsible for protection against the acute phase of Trypanosoma cruzi infection in mice
Autores: | Umekita,L.F.; Ramos,D.P.; Mota,I.
Data: | 1997-10-01
Ano: | 1997
Palavras-chave: | Trypanosoma cruzi; Clearance; Complement-mediated lysis; Protection.
Resumo: | A study was conducted on mice infected with strains Y and CL of Trypanosoma cruzi. The ability of anti-Y and anti-CL sera to induce complement-mediated lysis, immune clearance and protection against the acute phase of the infection was studied using homologous anti-Y or anti-CL serum tested with the Y or CL strain, or heterologous anti-Y serum tested with the CL strain or anti-CL serum tested with the Y strain. Complement-mediated lysis was induced by both homologous and heterologous antisera but protection was afforded only by homologous antisera. Immune clearance was induced by homologous but not by heterologous antisera. Antisera with high clearance ability were able to confer protection whereas antisera with high lytic ability were not. These results show a high correlation between the antibody ability to induce clearance and to confer protection and suggest that clearance rather than lysis is responsible for protection against the acute phase of the infection. The mechanism of antibody protection against the acute phase of the infection is discussed.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001000009
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X1997001000009
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.30 n.10 1997
Fonte: | info:eu-repo/semantics/openAccess