Data/hora: 11/06/2024 08:57:10

Provedor de dados: | 56
País: | Brazil
Título: | Adipose tissue is less responsive to food restriction anti-inflammatory effects than liver, muscle, and brain in mice
Autores: | Antunes,M.M.; de Almeida-Souza,C.B.; Godoy,G.; Crisma,A.R.; Masi,L.N.; Curi,R.; Bazotte,R.B.
Data: | 2019-01-01
Ano: | 2019
Palavras-chave: | Caloric restriction; Pro-inflammatory cytokines; Anti-inflammatory cytokines; Acetyl-CoA carboxylase; Disease prevention.
Resumo: | High caloric intake promotes chronic inflammation, insulin resistance, and chronic diseases such as type-2 diabetes, which may be prevented by food restriction (FR). The effect of FR on expression of pro-inflammatory and anti-inflammatory genes in adipose tissue, liver, muscle, and brain was compared. Male Swiss mice were submitted to FR (FR group) or had free access to food (control group) during 56 days. The liver, gastrocnemius muscle, brain, and epididymal white adipose tissue (WAT) were collected for analysis of gene expressions. FR attenuated inflammation in the liver, brain, and gastrocnemius muscle but did not markedly change inflammatory gene expression in epididymal WAT. We concluded that adipose tissue was less responsive to FR in terms of gene expression of pro-inflammatory and anti-inflammatory genes.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000100612
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/1414-431x20188150
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.52 n.1 2019
Fonte: | info:eu-repo/semantics/openAccess