Data/hora: 06/06/2024 15:32:30

Provedor de dados: 	57	
País: 	Brazil	
Título: 	Toxicology of Lapachol in rats: embryolethality	
Autores: 	GUERRA,M. de O.; MAZONI,A. S. B.; BRANDÃO,M. A. F.; PETERS,V. M.	
Data: 	2001-02-01	
Ano: 	2001	
Palavras-chave: 	Lapachol; Embryotoxicity; Rat.	
Resumo: 	Lapachol is a naphtoquinone with therapeutic potential against enterovirus, Chagas disease and is also used as an antimalarial and antiinflamatory agent. In order to study teratogenic potential of Lapachol, pregnant Wistar rats were treated with 0.5 ml of distilled water (control group); 0.5 ml of hydroalcoholic solution (vehicle group) and 10 mg of Lapachol in 0.5 ml of hydroalcoholic solution (treated group) by oral gavage from the 8th to the 12th day of pregnancy. The following variables were observed: maternal body weight on days 1, 6, l5 and 21 and food intake on days 2, 6, 15 and 21 of pregnancy. The number of live and dead fetuses and the sites of resorptions were counted. The ovaries were weighed and the corpora lutea were counted. Data were analyzed by ANOVA-one way, Dunnett test and the chi square test. Significance level test alpha = 0.05. Results have shown that mothers were unaffected but there were a 99.2% of fetus mortality, indicative of a strong abortifacient effect of Lapachol in rats.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034-71082001000100021	
Editor: 	Instituto Internacional de Ecologia	
Relação: 	10.1590/S0034-71082001000100021	
Formato: 	text/html	
Fonte: 	Revista Brasileira de Biologia  v.61 n.1 2001	
Fonte: 	info:eu-repo/semantics/openAccess