Data/hora: 02/06/2024 13:07:01

Provedor de dados: 	58	
País: 	Brazil	
Título: 	Activation of the alternative complement pathway in canine normal serum by Paracoccidioides brasiliensis	
Autores: 	Bianchini,A.A.C.; Petroni,T.F.; Fedatto,P.F.; Bianchini,R.R.; Venancio,E.J.; Itano,E.N.; Ono,M.A.	
Data: 	2009-06-01	
Ano: 	2009	
Palavras-chave: 	Paracoccidioidomycosis; Dog; Complement.	
Resumo: 	The dimorphic fungus Paracoccidioides brasiliensis is the etiological agent of paracoccidioidomycosis, a human granulomatous disease. Recently the first case of natural disease in dogs was reported. The complement system is an important effector component of humoral immunity against infectious agents. Therefore, the aim of this study was to evaluate the activation of the dog alternative complement pathway by P. brasiliensis. Initially, the ability of erythrocytes of guinea pig, rabbit, sheep, chicken and swine to activate the dog alternative pathway was evaluated. The guinea pig erythrocytes showed the greatest capacity to activate dog alternative pathway. The alternative (AH50) hemolytic activity was evaluated in 27 serum samples from healthy dogs and the mean values were 87.2 AH50/ml. No significant differences were observed in relation to sex and age. The alternative pathway activation by P. brasiliensis was higher in serum samples from adult dogs when compared to puppies and aged dogs (p &lt; 0.05). This is the first report of dog alternative complement pathway activation by P. brasiliensis and suggests that it may play a protective role in canine paracoccidioidomycosis.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822009000200005	
Editor: 	Sociedade Brasileira de Microbiologia	
Relação: 	10.1590/S1517-83822009000200005	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Microbiology  v.40 n.2 2009	
Fonte: 	info:eu-repo/semantics/openAccess