Data/hora: 10/06/2024 16:55:17

Provedor de dados: 	58	
País: 	Brazil	
Título: 	New antimicrobial combinations: substituted chalcones- oxacillin against methicillin resistant Staphylococcus aureus	
Autores: 	Talia,Juan Manuel; Debattista,Nora Beatriz; Pappano,Nora Beatriz.	
Data: 	2011-06-01	
Ano: 	2011	
Palavras-chave: 	Substituted chalcones; Oxacillin; Combinations; Antimicrobial; S. aureus.	
Resumo: 	Staphylococcus aureus, the most virulent Staphylococcus species, is also the prevalent pathogen isolated from hospitalized patients and the second most common from patients in outpatient settings. In general, bacteria have the genetic ability to transmit and acquire resistance to drugs, which are utilized as therapeutic agents. Related studies of antimicrobial activity indicate that crude extracts containing flavonoids, triterpenes and steroids have showed significative activity against several Staphylococcus aureus strains. Combination effects between flavonoids and antibiotics also have been reported. The aim of the present work was to investigate in vitro synergism between several chalcones substituted in combination with oxacillin, an antibiotic used conventionally against S. aureus ATCC 43 300 that is resistant to meticillin, using the kinetic turbidimetric method developed earlier. The results were satisfactory for all assayed combinations and in accordance with the mechanism of bacteriostatic inhibition previously proposed, except for 2´,4´-dihydroxy-3´-methoxychalcone - oxacillin. The best combination was 2´,3´-dihydroxychalcone - oxacillin (MIC: 11.2 μg/mL). Further investigations are needed to characterize the interaction mechanism with antibiotics. Thus, chalcones - oxacillin combination could lead to the development of new antibiotics against methicillin resistant S. aureus infection.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822011000200010	
Editor: 	Sociedade Brasileira de Microbiologia	
Relação: 	10.1590/S1517-83822011000200010	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Microbiology  v.42 n.2 2011	
Fonte: 	info:eu-repo/semantics/openAccess