Data/hora: 10/06/2024 09:25:10

Provedor de dados: 	58	
País: 	Brazil	
Título: 	Anti-Mycobacterium tuberculosis activity of fungus Phomopsis stipata	
Autores: 	Prince,Karina Andrade de; Sordi,Renata; Pavan,Fernando Rogério; Santos,Adolfo Carlos Barreto; Araujo,Angela R.; Leite,Sergio R.A.; Leite,Clarice Q. F.	
Data: 	2012-03-01	
Ano: 	2012	
Palavras-chave: 	Phomopsis stipata; Antimycobacterial activity; Mycobacterium tuberculosis.	
Resumo: 	Our purpose was to determine the anti-Mycobacterium tuberculosis activity of the metabolites produced by the endophitic fungus Phomopsis stipata (Lib.) B. Sutton, (Diaporthaceae), cultivated in different media. The antimycobacterial activity was assessed through the Resazurin Microtiter Assay (REMA) and the cytotoxicity test performed on macrophage cell line. The extracts derived from fungi grown on Corn Medium and Potato Dextrose Broth presented the smallest values of Minimum Inhibitory Concentration (MIC) and low cytotoxicity, which implies a high selectivity index. This is the first report on the chemical composition and antitubercular activity of metabolites of P. stipata, as well as the influence of culture medium on these properties.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822012000100024	
Editor: 	Sociedade Brasileira de Microbiologia	
Relação: 	10.1590/S1517-83822012000100024	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Microbiology  v.43 n.1 2012	
Fonte: 	info:eu-repo/semantics/openAccess