Data/hora: 14/06/2024 01:25:55

Provedor de dados: | 58
País: | Brazil
Título: | Proinflammatory signal transduction pathway induced by Shigella flexneri porins in caco-2 cells
Autores: | Elena,Grimaldi; Giovanna,Donnarumma; Brunella,Perfetto; Anna,De Filippis; Alessandro,Melito; Antonietta,Tufano Maria.
Data: | 2009-09-01
Ano: | 2009
Palavras-chave: | Porins; TLRs; PAMPs; Shigella flexneri; Shigella flexneri.
Resumo: | The recognition of bacterial components on the intestinal epithelial cells occurs through the toll-like receptors and is followed by the induction of an effective innate immune response. We analyzed receptor expression and signaling pathways involved in activation of human colon adenocarcinoma cells after stimulation with porins and LPS of Shigella flexneri. We also analyzed the expression and production of some cytokines, of intercellular adhesion molecule-1, of antimicrobial peptides human ²-defensins, and of the inducible form of nitric oxide synthase. Our data demonstrate that TLR2 is involved in porin recognition, whereas TLR4 with MD2, is required for LPS recognition.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822009000300036
Editor: | Sociedade Brasileira de Microbiologia
Relação: | 10.1590/S1517-83822009000300036
Formato: | text/html
Fonte: | Brazilian Journal of Microbiology  v.40 n.3 2009
Fonte: | info:eu-repo/semantics/openAccess