Data/hora: 06/06/2024 13:38:34

Provedor de dados: 	58	
País: 	Brazil	
Título: 	Quinolone resistance and ornithine decarboxylation activity in lactose-negative Escherichia coli	
Autores: 	Gomig,Franciane; Galvão,Carolina Weigert; Freitas,Denis Leandro de; Labas,Larissa; Etto,Rafael Mazer; Esmerino,Luiz Antonio; Lima,Marcelo Andrade de; Appel,Marcia Helena; Zanata,Silvio Marques; Steffens,Maria Berenice Reynaud; Nader,Helena Bonciani; Silveira,Rafael Bertoni da.	
Data: 	2015-09-01	
Ano: 	2015	
Palavras-chave: 	ODC; GyrA; ParC; Uropathogenic.	
Resumo: 	Quinolones and fluoroquinolones are widely used to treat uropathogenic Escherichia coli infections. Bacterial resistance to these antimicrobials primarily involves mutations in gyrA and parC genes. To date, no studies have examined the potential relationship between biochemical characteristics and quinolone resistance in uropathogenic E. coli strains. The present work analyzed the quinolone sensitivity and biochemical activities of fifty-eight lactose-negative uropathogenic E. coli strains. A high percentage of the isolates (48.3%) was found to be resistant to at least one of the tested quinolones, and DNA sequencing revealed quinolone resistant determining region gyrA and parC mutations in the multi-resistant isolates. Statistical analyses suggested that the lack of ornithine decarboxylase (ODC) activity is correlated with quinolone resistance. Despite the low number of isolates examined, this is the first study correlating these characteristics in lactose-negative E. coli isolates.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822015000300753	
Editor: 	Sociedade Brasileira de Microbiologia	
Relação: 	10.1590/S1517-838246320131291	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Microbiology  v.46 n.3 2015	
Fonte: 	info:eu-repo/semantics/openAccess