Data/hora: 06/06/2024 15:24:01

Provedor de dados: | 58
País: | Brazil
Título: | Antimycobacterial susceptibility testing methods for natural products research
Autores: | Sánchez,Juan Gabriel Bueno; Kouznetsov,Vladimir V.
Data: | 2010-06-01
Ano: | 2010
Palavras-chave: | Natural products; M. tuberculosis; Susceptibility testing.
Resumo: | The emergence of multidrug-resistant strains of Mycobacterium tuberculosis underscores the need of continuous developments on new and efficient methods to determine the susceptibility of isolates of M. tuberculosis in the search for novel antimicrobial agents. Natural products constitute an important source of new drugs, but design and implementation of antimycobacterial susceptibility testing methods are necessary for evaluate the different extracts and compounds. A number of biological assay methodologies are in current use, ranging from the classical disk diffusion and broth dilution assay format, to radiorespirometric (BACTEC), dye-based, and fluorescent/luminescence reporter assays. This review presents an analysis on the in vitro susceptibility testing methods developed for determinate antitubercular activity in natural products and related compounds (semi-synthetic natural products and natural products-derived compounds) and the criteria to select the adequate method for determination of biological activity of new natural products.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822010000200001
Editor: | Sociedade Brasileira de Microbiologia
Relação: | 10.1590/S1517-83822010000200001
Formato: | text/html
Fonte: | Brazilian Journal of Microbiology  v.41 n.2 2010
Fonte: | info:eu-repo/semantics/openAccess