Data/hora: 10/06/2024 01:03:33

Provedor de dados: 	58	
País: 	Brazil	
Título: 	Antifungal susceptibility of clinical and environmental Cryptococcus neoformans and Cryptococcus gattii isolates in Jabalpur, a city of Madhya Pradesh in Central India	
Autores: 	Gutch,Ruchi Sethi; Nawange,Shesh Rao; Singh,Shankar Mohan; Yadu,Ruchika; Tiwari,Aditi; Gumasta,Richa; Kavishwar,Arvind.	
Data: 	2015-12-01	
Ano: 	2015	
Palavras-chave: 	Cryptococcus neoformans; Cryptococcus gattii; Minimum inhibitory concentration; Azoles; Central India.	
Resumo: 	In this study, we present antifungal susceptibility data of clinical and environmental isolates of Central Indian Cryptococcus neoformans (Serotype A, n = 8 and n = 50 respectively) and Cryptococcus gattii (Serotype B, n = 01 and n = 04 respectively). Susceptibilities to fluconazole, itraconazole and ketoconazole were determined by using NCCLS broth micro-dilution methodology. The total number of resistant strains for fluconazole in case of C. neoformans and C. gattii showed a significant difference by using chi-square test (p &lt; 0.05*), while considering fisher's exact p value was nonsignificant (p &gt; 0.05). However, the total number of resistant strains for itraconazole and ketoconazole was not found statistically significant. A comparison of geometric means of clinical and environmental strains of C. gattii and C. neoformans was not found statistically significant using student ‘t’ test (p value &gt; 0.05 NS). Though less, the antifungal data obtained in this study suggests that primary resistance among environmental and clinical isolates of C. neoformans and C. gattii against tested antifungal was present and C. gattii comparatively was less susceptible than C. neoformans var. grubii isolates to fluconazole than to itraconazole and ketoconazole. A continuous surveillance of antifungal susceptibility of clinical and environmental isolates of C. neoformans and C. gattii is desirable to monitor the emergence of any resistant strains for better management of cryptococcosis patients.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822015000401125	
Editor: 	Sociedade Brasileira de Microbiologia	
Relação: 	10.1590/S1517-838246420140564	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Microbiology  v.46 n.4 2015	
Fonte: 	info:eu-repo/semantics/openAccess