Data/hora: 11/06/2024 01:32:31

Provedor de dados: | 58
País: | Brazil
Título: | Live bacterial vaccine vectors: An overview
Autores: | Silva,Adilson José da; Zangirolami,Teresa Cristina; Novo-Mansur,Maria Teresa Marques; Giordano,Roberto de Campos; Martins,Elizabeth Angélica Leme.
Data: | 2014-12-01
Ano: | 2014
Palavras-chave: | Bacterial vector; Vaccine delivery system; DNA vaccine; Cancer vaccine; Antigen presentation.
Resumo: | Genetically attenuated microorganisms, pathogens, and some commensal bacteria can be engineered to deliver recombinant heterologous antigens to stimulate the host immune system, while still offering good levels of safety. A key feature of these live vectors is their capacity to stimulate mucosal as well as humoral and/or cellular systemic immunity. This enables the use of different forms of vaccination to prevent pathogen colonization of mucosal tissues, the front door for many infectious agents. Furthermore, delivery of DNA vaccines and immune system stimulatory molecules, such as cytokines, can be achieved using these special carriers, whose adjuvant properties and, sometimes, invasive capacities enhance the immune response. More recently, the unique features and versatility of these vectors have also been exploited to develop anti-cancer vaccines, where tumor-associated antigens, cytokines, and DNA or RNA molecules are delivered. Different strategies and genetic tools are constantly being developed, increasing the antigenic potential of agents delivered by these systems, opening fresh perspectives for the deployment of vehicles for new purposes. Here we summarize the main characteristics of the different types of live bacterial vectors and discuss new applications of these delivery systems in the field of vaccinology.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822014000400001
Editor: | Sociedade Brasileira de Microbiologia
Relação: | 10.1590/S1517-83822014000400001
Formato: | text/html
Fonte: | Brazilian Journal of Microbiology  v.45 n.4 2014
Fonte: | info:eu-repo/semantics/openAccess