Data/hora: 05/06/2024 10:18:08

Provedor de dados: 	58	
País: 	Brazil	
Título: 	Efficacy of aqueous garlic extract on growth, aflatoxin B1 production, and Cyto-morphological aberrations of Aspergillus flavus, causing human ophthalmic infection: topical treatment of A. flavus keratitis	
Autores: 	Ismaiel,Ahmed A.; Rabie,Gamal H.; Kenawey,Saied E.M.; EL-Aal,Marwa A. Abd.	
Data: 	2012-12-01	
Ano: 	2012	
Palavras-chave: 	Aspergillus flavus. Garlic; Antifungal; Keratitis; Microscopic examination; Aflatoxin B1.	
Resumo: 	By using agar well diffusion assay, antifungal activity of aqueous extract prepared from Egyptian garlic (Allium sativum L.) was evaluated in vitro against two strains of Aspergillus flavus (OC1 and OC10) causing human ocular infection. The recorded minimum inhibitory concentration (MIC) for growth inhibition of both strains was 3.60 mg/ml. Aqueous garlic extract (AGE) was used in successive in vivo tests as an attempt to cure rabbit's fungal keratitis caused by A. flavus OC1. Findings showed that diluted preparation of AGE was effective topical antifungal agent and succeeded to cure severe A. flavus keratitis in a time course less than 10 days without any observable side effects. Microscopic examination showed that AGE induced deleterious cyto-morphological aberrations inA. flavus target cells. AGE applied to Czapek's broth via contact method was more effective on growth, spores and aflatoxin B1 production than AGE applied to the same broth at the same concentration via fumigation method.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822012000400017	
Editor: 	Sociedade Brasileira de Microbiologia	
Relação: 	10.1590/S1517-83822012000400017	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Microbiology  v.43 n.4 2012	
Fonte: 	info:eu-repo/semantics/openAccess