Data/hora: 06/06/2024 02:46:33

Provedor de dados: | 58
País: | Brazil
Título: | Bacteremia and meningitis caused by OXA-23-producing Acinetobacter baumannii – molecular characterization and susceptibility testing for alternative antibiotics
Autores: | Schuertz,Kamile Francine; Tuon,Felipe Francisco; Palmeiro,Jussara Kasuko; Conte,Danieli; Telles,João Paulo Marochi; Trevisoli,Lucas Eduardo; Dalla-Costa,Libera Maria.
Data: | 2018-01-01
Ano: | 2018
Palavras-chave: | Acinetobacter baumannii; Oxacillinases; Carbapenem; Multidrug resistance; Doxycycline.
Resumo: | Abstract  Background: Carbapenem-resistant Acinetobacter baumannii infection is a concern in developing countries due to high incidence, few therapeutic options, and increasing costs.  Objective: Characterize and analyze the antibiotic susceptibility patterns of carbapenem-resistant A. baumannii isolates and evaluate clinical data of meningitis and bacteremia caused by this microorganism.  Methods: Twenty-six A. baumannii isolates from 23 patients were identified by MALDI-TOF and automated methods and genotyped using pulsed field genotyping electrophoresis. Clinical data and outcomes were evaluated. Susceptibility of isolates to colistin, tigecycline, meropenem, imipenem, and doxycycline was determined.  Results: Mortality due to A. baumannii infections was 73.91%; all patients with meningitis and 7/8 patients with ventilator-associated pneumonia died. All isolates were susceptibility to polymyxin (100%; MIC50, MIC90: 1 µg/mL, 1 µg/mL) and colistin (100%; MIC50, MIC90: 2 µg/mL, 2 µg/mL), and 92% were susceptible to tigecycline (MIC50, MIC90: 1 µg/mL, 1 µg/mL) and doxycycline (MIC50, MIC90: 2 µg/mL, 2 µg/mL). bla OXA-23 was identified in 24 isolates. Molecular typing showed 8 different patterns: 13 isolates belonged to pattern A (50%).  Conclusion: Carbapenem-resistant A. baumannii infections mortality is high. Alternative antimicrobial therapy (doxycycline) for selected patients with carbapenem-resistant A. baumannii infection should be considered.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822018000500199
Editor: | Sociedade Brasileira de Microbiologia
Relação: | 10.1016/j.bjm.2018.04.002
Formato: | text/html
Fonte: | Brazilian Journal of Microbiology  v.49 suppl.1 2018
Fonte: | info:eu-repo/semantics/openAccess