Data/hora: 06/06/2024 18:00:45

Provedor de dados: | 58
País: | Brazil
Título: | DEFB1 gene polymorphisms and tuberculosis in a Northeastern Brazilian population
Autores: | Silva,Ronaldo Celerino da; Cruz,Heidi Lacerda Alves da; Brandão,Lucas André Cavalcanti; Guimarães,Rafael Lima; Montenegro,Lilian Maria Lapa; Schindler,Haiana Charifker; Segat,Ludovica; Crovella,Sergio.
Data: | 2016-06-01
Ano: | 2016
Palavras-chave: | Tuberculosis; Innate immunity; DEFB1; Genotyping; Polymorphism.
Resumo: | Abstract β-Defensin-1, an antimicrobial peptide encoded by the DEFB1 gene, is known to play an important role in lung mucosal immunity. In our association study we analyzed three DEFB1 functional polymorphisms -52G&gt;A (rs1799946), -44C&gt;G (rs1800972) and -20G&gt;A (rs11362) in 92 tuberculosis patients and 286 healthy controls, both from Northeast Brazil: no association was found between the studied DEFB1 polymorphisms and the disease. However we cannot exclude that this lack of association could be due to the low number of subjects analyzed, as suggested by the low statistical power achieved for the three analyzed SNPs (values between 0.16 and 0.50).
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822016000200389
Editor: | Sociedade Brasileira de Microbiologia
Relação: | 10.1016/j.bjm.2015.09.001
Formato: | text/html
Fonte: | Brazilian Journal of Microbiology  v.47 n.2 2016
Fonte: | info:eu-repo/semantics/openAccess