Data/hora: 07/06/2024 05:21:45

Provedor de dados: 	58	
País: 	Brazil	
Título: 	Levan from Bacillus subtilis Natto: its effects in normal and in streptozotocin-diabetic rats	
Autores: 	Melo,Fernando Cesar Bazani Cabral de; Zaia,Cássia Thaïs Bussamra Viera; Celligoi,Maria Antonia Pedrine Colabone.	
Data: 	2012-12-01	
Ano: 	2012	
Palavras-chave: 	Levan; Bacillus subtilis Natto; Hypoglycemia.	
Resumo: 	Levan is an exopolysaccharide of fructose primarily linked by β-(2→6) glycosidic bonds with some β-(2→1) branched chains. Due to its chemical properties, levan has possible applications in both the food and pharmaceutical industries. Bacillus subtilis is a promising industrial levan producer, as it ferments sucrose and has a high levan-formation capacity. A new strain of B. subtilis was recently isolated from Japanese food natto, and it has produced levan in large quantities. For future pharmaceutical applications, this study aimed to investigate the effects of levan produced by B. subtilis Natto, mainly as potential hypoglycemic agent, (previously optimized with a molecular weight equal to 72.37 and 4,146 kDa) in Wistar male rats with diabetes induced by streptozotocin and non-diabetic rats and to monitor their plasma cholesterol and triacylglycerol levels. After 15 days of experimentation, the animals were sacrificed, and their blood samples were analyzed. The results, compared using analysis of variance, demonstrated that for this type of levan, a hypoglycemic effect was not observed, as there was no improvement of diabetes symptoms during the experiment. However, levan did not affect any studied parameters in normal rats, indicating that the exopolysaccharide can be used for other purposes.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822012000400046	
Editor: 	Sociedade Brasileira de Microbiologia	
Relação: 	10.1590/S1517-83822012000400046	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Microbiology  v.43 n.4 2012	
Fonte: 	info:eu-repo/semantics/openAccess