Data/hora: 11/06/2024 04:43:40

Provedor de dados: 	59	
País: 	Brazil	
Título: 	Structure-biological activity relationship of synthetic trihydroxilated chalcones	
Autores: 	Devia,Cristina M.; Pappano,Nora B.; Debattista,Nora B.	
Data: 	1998-10-01	
Ano: 	1998	
Palavras-chave: 	Bacteriostatic activity; Structure-activity relationship; Flavonoids; Trihydroxylated chalcones.	
Resumo: 	The bacteriostatic activity of 2’,4’,2-trihydroxychalcone; 2’,4’,3-trihydroxychalcone and 2’,4’,4-trihydroxychalcone, prepared by condensation of 2,4-dihydroxyacetophenone and benzaldehyde substituted, against Staphylococcus aureus ATCC 25923 was assayed by agar plate method. The three compounds presented important inhibition halos. In order to elucidate structure-activity relationships, the minimal inhibitory concentrations against S. aureus were determined by the broth dilution method and the results obtained were compared to that of 2',4'-dihydroxychalcone. The sequence observed was: MIC 2’,4’,3-(OH)3 &amp;gt; MIC 2’,4’-(OH)2 &amp;gt; MIC 2’,4’,4-(OH)3 &amp;gt; &amp;gt; MIC 2’,4’,2-(OH)3. These results showed that the introduction of an electron donating group (-OH) in the aromatic B-ring causes an increase in bioactivity, and that the intensity of action depends on the position of the OH substitute.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37141998000400014	
Editor: 	Sociedade Brasileira de Microbiologia	
Relação: 	10.1590/S0001-37141998000400014	
Formato: 	text/html	
Fonte: 	Revista de Microbiologia  v.29 n.4 1998	
Fonte: 	info:eu-repo/semantics/openAccess