Data/hora: 05/06/2024 01:10:40

Provedor de dados: | 60
País: | Brazil
Título: | Simultaneous RP-HPLC determination of sparfloxacin and dexamethasone in pharmaceutical formulations
Autores: | Razzaq,Syed Naeem; Ashfaq,Muhammad; Mariam,Irfana; Khan,Islam Ullah; Razzaq,Syed Saleem.
Data: | 2013-06-01
Ano: | 2013
Palavras-chave: | RP-HPLC; Sparfloxacin; Dexamethasone; Degradation products; Stability studies.
Resumo: | The present study describes the development and subsequent validation of simple and accurate stability indicating RP-HPLC method for the determination of sparfloxacin and dexamethasone in pharmaceutical formulations in the presence of their stress-induced degradation products. Both the drugs and their stress-induced degradation products were separated within 10 minutes using C8 column and mixture of methanol and 0.02 M phosphate buffer pH 3.0 (60:40 v/v, respectively) as mobile phase at 270 nm using diode array detector. Regression analysis showed linearity in the range of 15-105 µg/mL for sparfloxacin and 5-35 µg/mL for dexamethasone. All the analytes were adequately resolved with acceptable tailing. Peak purity of the two drugs was also greater than 0.9999, showing no co-elution peaks. The developed method was applied for simultaneous determination of sparfloxacin and dexamethasone in pharmaceutical formulations for stability studies.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000200012
Editor: | Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação: | 10.1590/S1984-82502013000200012
Formato: | text/html
Fonte: | Brazilian Journal of Pharmaceutical Sciences  v.49 n.2 2013
Fonte: | info:eu-repo/semantics/openAccess