Data/hora: 09/06/2024 11:55:46

Provedor de dados: | 60
País: | Brazil
Título: | Biological properties of water-soluble phosphorhydrazone dendrimers
Autores: | Caminade,Anne-Marie; Turrin,Cédric-Olivier; Majoral,Jean-Pierre.
Data: | 2013-01-01
Ano: | 2013
Palavras-chave: | Dendrimers; Phosphorhydrazone dendrimers; Biological properties; Nanomedicine.
Resumo: | Dendrimers are hyperbranched and perfectly defined macromolecules, constituted of branches emanating from a central core in an iterative fashion. Phosphorhydrazone dendrimers constitute a special family of dendrimers, possessing one phosphorus atom at each branching point. The internal structure of these dendrimers is hydrophobic, but hydrophilic terminal groups can induce the solubility of the whole structure in water. Indeed, the properties of these compounds are mainly driven by the type of terminal groups their bear; this is especially true for the biological properties. For instance, positively charged terminal groups are efficient for transfection experiments, as drug carriers, as anti-prion agents, and as inhibitor of the aggregation of Alzheimer's peptides, whereas negatively charged dendrimers have anti-HIV properties and can influence the human immune system, leading to anti-inflammatory properties usable against rheumatoid arthritis. This review will give the most representative examples of the biological properties of water-soluble phosphorhydrazone dendrimers, organized depending on the type of terminal groups they bear.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000700004
Editor: | Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação: | 10.1590/S1984-82502013000700004
Formato: | text/html
Fonte: | Brazilian Journal of Pharmaceutical Sciences  v.49 n.spe 2013
Fonte: | info:eu-repo/semantics/openAccess