Data/hora: 07/06/2024 02:30:07

Provedor de dados: | 60
País: | Brazil
Título: | Mucoadhesive microemulsion of ibuprofen: design and evaluation for brain targeting efficiency through intranasal route
Autores: | Mandal,Surjyanarayan; Mandal,Snigdha Das; Chuttani,Krishna; Subudhi,Bharat Bhushan.
Data: | 2015-09-01
Ano: | 2015
Palavras-chave: | Ibuprofen/brain-targeting; Ibuprofen/intranasal administration; Ibuprofen/mucoadhesion; Mucoadhesive microemulsion gel; Drugs/design; Transmission electron microscopy.
Resumo: | This study aimed at designing mucoadhesive microemulsion gel to enhance the brain uptake of Ibuprofen through intranasal route. Ibuprofen loaded mucoadhesive microemulsion (MMEI) was developed by incorporating polycarbophil as mucoadhesive polymer into Capmul MCM based optimal microemulsion (MEI) and was subjected to characterization, stability, mucoadhesion and naso-ciliotoxicity study. Brain uptake of ibuprofen via nasal route was studied by performing biodistribution study in Swiss albino rats. MEI was found to be transparent, stable and non ciliotoxic with 66.29 ± 4.15 nm, -20.9 ± 3.98 mV and 98.66 ± 1.01% as average globule size, zeta potential and drug content respectively. Transmission Electron Microscopy (TEM) study revealed the narrow globule size distribution of MEI. Following single intranasal administration of MMEI and MEI at a dose of 2.86 mg/kg, uptake of ibuprofen in the olfactory bulb was around 3.0 and 1.7 folds compared with intravenous injection of ibuprofen solution (IDS). The ratios of AUC in brain tissues to that in plasma obtained after nasal administration of MMEI were significantly higher than those after intravenous administration of IDS. Findings of the present investigation revealed that the developed mucoadhesive microemulsion gel could be a promising approach for brain targeting of ibuprofen through intranasal route.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000300721
Editor: | Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação: | 10.1590/S1984-82502015000300024
Formato: | text/html
Fonte: | Brazilian Journal of Pharmaceutical Sciences  v.51 n.3 2015
Fonte: | info:eu-repo/semantics/openAccess