Data/hora: 13/06/2024 02:59:23

Provedor de dados: | 60
País: | Brazil
Título: | In Vitro additive effect on griseofulvin and terbinafine combinations against multidrug-resistant dermatophytes
Autores: | Lana,Aline Jacobi Dalla; Pippi,Bruna; Carvalho,Anderson Ramos; Moraes,Renata Cougo; Kaiser,Samuel; Ortega,George Gonzalez; Fuentefria,Alexandre Meneghello; Silveira,Gustavo Pozza.
Data: | 2018-01-01
Ano: | 2018
Palavras-chave: | Griseofulvin; Terbinafine; Dermatophyte; Multidrug-resistant fungi; Drug combination.
Resumo: | ABSTRACT Griseofulvin (GF) and terbinafine (TF) are commonly used drugs to treat dermatophytosis, a fungal infection of the skin. Today there is an increase in drug resistance to these antifungals which highlight the need for alternative synergistic therapies. Minimum Inhibitory Concentration (MIC) of GF and TF were determined against fungi clinical isolates from local hospitals with values ranging 0.03-2.0 µg mL-1 and 0.24-4.0 µg mL-1, respectively. A checkboard test was used to determine the combination of GF:TF which could induce an additive effect against the fungi isolates Multidrug-resistant isolates showed susceptibility after treatment with 16:2 µg mL-1 GF:TF. An MTT assay further verified that GF and TF combinations have greater additive effect against pathological and multidrug-resistant isolates than antifungals alone. Herein we disclose GF:TF combinations that could constitute as a possible new anti-dermatophyte therapy.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200623
Editor: | Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação: | 10.1590/s2175-97902018000217149
Formato: | text/html
Fonte: | Brazilian Journal of Pharmaceutical Sciences  v.54 n.2 2018
Fonte: | info:eu-repo/semantics/openAccess