Data/hora: 10/06/2024 09:17:05

Provedor de dados: 	60	
País: 	Brazil	
Título: 	Categorization of the main descriptors of different ampicillin crystal habits	
Autores: 	Flórez-Acosta,Oscar; Tobón-Zapata,Gloria; Valencia-Velasquez,Jaime.	
Data: 	2010-12-01	
Ano: 	2010	
Palavras-chave: 	Multisource solids; Morphological descriptors; Fourier descriptors; Crystal habits; Multivariate analysis.	
Resumo: 	With the purpose of enabling the analysis by digital methods of particles of multisource pharmaceutical raw materials, this study analyzed different crystal habits of ampicillin particles, by grouping the external shapes obtained from 3 different solvents (acetonitrile, ethanol, and methanol), thereby reducing the number of descriptors necessary to adequately represent each shape. For this purpose, a selection of morphological descriptors was used including: circularity, roughness, roundness, compactness, aspect ratio, effective diameter, solidity, convexity, fractal dimension, and 10 Complex Fourier descriptors. These measures cover highly diverse morphological properties and define the crystal habit of a particle. Principal Component Analysis (PCA) and the Cluster Analysis (CA) were the grouping techniques used, which demonstrated the possibility of using between 2 and 4 descriptors instead of the 18 proposed initially.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000400009	
Editor: 	Universidade de São Paulo, Faculdade de Ciências Farmacêuticas	
Relação: 	10.1590/S1984-82502010000400009	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Pharmaceutical Sciences  v.46 n.4 2010	
Fonte: 	info:eu-repo/semantics/openAccess