Data/hora: 13/06/2024 00:40:22

Provedor de dados: | 60
País: | Brazil
Título: | Phenobarbital loaded microemulsion: development, kinetic release and quality control
Autores: | Figueiredo,Kayo Alves; Neves,Jamilly Kelly Oliveira; Silva,José Alexsandro da; Freitas,Rivelilson Mendes de; Carvalho,André Luis Menezes.
Data: | 2016-06-01
Ano: | 2016
Palavras-chave: | Microemulsion/physicochemical characterization; Microemulsion/In vitro release; Phenobarbital/microemulsion system/evaluation; Nanotechnology.
Resumo: | ABSTRACT This study aimed to obtain and characterize a microemulsion (ME) containing phenobarbital (PB). The PB was incorporated in the proportion of 5% and 10% in a microemulsion system containing Labrasol(r), ethanol, isopropyl myristate and purified water. The physicochemical characterization was performed and the primary stability of the ME was evaluated. An analytical method was developed using spectrophotometry in UV  = 242 nm. The kinetics of the in vitro release (Franz model) of the ME and the emulsion (EM) containing PB was evaluated. The incorporation of PB into ME at concentrations of 5 and 10% did not change pH and resistance to centrifugation. There was an increase in particle size, a decrease of conductivity and a change in the refractive index in relation to placebo ME. The ME remained stable in preliminary stability tests. The analytical method proved to be specific, linear, precise, accurate and robust. Regarding the kinetics of the in vitro release, ME obtained an in vitro release profile greater than the EM containing PB. Thus, the obtained ME has a potential for future transdermal application, being able to compose a drug delivery system for the treatment of epilepsy.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000200251
Editor: | Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação: | 10.1590/S1984-82502016000200003
Formato: | text/html
Fonte: | Brazilian Journal of Pharmaceutical Sciences  v.52 n.2 2016
Fonte: | info:eu-repo/semantics/openAccess