Data/hora: 05/06/2024 02:27:36

Provedor de dados: | 60
País: | Brazil
Título: | Preclinical evaluation of nephroprotective potential of a probiotic formulation LOBUN on Cyclosporine-A induced renal dysfunction in Wistar rats
Autores: | Venkateswarlu,Kambham; Heerasingh,Thakur; Babu,Chilamakuru Naresh; Triveni,Singirisetty; Manasa,Suroju; Babu,Thumati Nagendra Bhaskar.
Data: | 2017-01-01
Ano: | 2017
Palavras-chave: | Cyclosporine-A; LOBUN/effects; LOBUN/effects/evaluation; Nephroprotective activity; Prebiotics; Probiotics; Chronic Kidney Disease/study.
Resumo: | ABSTRACT The aim of present study was to evaluate the nephroprotective effect of probiotic formulation LOBUN on Cyclosporine A (CsA) induced renal dysfunction in Wistar rats. CsA (20 mg/kg body weight s.c) was administered for 15 days to cause renal dysfunction in Wistar rats. The probiotic formulation LOBUN was administered with the dose of 500 mg/kg body weight (p.o) for twice (TGI) and thrice a day (TGII). The samples were analyzed for the parameters like blood urine nitrogen (BUN), serum creatinine, serum uric acid, total serum protein and urine proteins, urine potassium, urine sodium. The renal functional and histopathological studies revealed that the oral administration of probiotic formulation LOBUN has provided appreciable renoprotection and possibly alleviated the symptoms of Chronic Kidney Disease (CKD) at the dose of 500 mg/kg body weight administered thrice a day and also the results were supported by histopathological findings.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000200605
Editor: | Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação: | 10.1590/s2175-97902017000216041
Formato: | text/html
Fonte: | Brazilian Journal of Pharmaceutical Sciences  v.53 n.2 2017
Fonte: | info:eu-repo/semantics/openAccess