Data/hora: 16/06/2024 07:12:01

Provedor de dados: | 60
País: | Brazil
Título: | Synergistic effect of ibuprofen with itraconazole and fluconazole against Cryptococcus neoformans
Autores: | Rocha,Letícia Fernandes da; Pippi,Bruna; Fuentefria,Alexandre Meneghello; Mezzari,Adelina.
Data: | 2020-01-01
Ano: | 2020
Palavras-chave: | Cryptococcus neoformans; Ibuprofen; Itraconazole; Fluconazole; Synergism.
Resumo: | The present study investigated the association of the non-steroidal anti-inflammatory drug ibuprofen with itraconazole, fluconazole and amphotericin B against Cryptococcus neoformans isolates. The minimal inhibitory concentration (MIC) was found according to M27-A3 protocol and in vitro interactions were evaluated using checkerboard microdilution method. Synergism was demonstrated between azoles and ibuprofen for most isolates. However, no synergistic effects were seen when amphotericin B was combined with ibuprofen. Therefore, our results suggest that ibuprofen presents clinical potential when combined with azole drugs in the treatment of cryptococcosis.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100577
Editor: | Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação: | 10.1590/s2175-97902019000318599
Formato: | text/html
Fonte: | Brazilian Journal of Pharmaceutical Sciences  v.56 2020
Fonte: | info:eu-repo/semantics/openAccess