Data/hora: 13/06/2024 15:53:49

Provedor de dados: | 60
País: | Brazil
Título: | Freeze-drying microscopy in mathematical modeling of a biomaterial freeze-drying
Autores: | Borgognoni,Camila Figueiredo; Bevilacqua,Joyce da Silva; Pitombo,Ronaldo Nogueira de Moraes.
Data: | 2012-06-01
Ano: | 2012
Palavras-chave: | Freeze-drying microscopy; Bovine pericardium; Mathematical modeling.
Resumo: | Transplantation brings hope for many patients. A multidisciplinary approach on this field aims at creating biologically functional tissues to be used as implants and prostheses. The freeze-drying process allows the fundamental properties of these materials to be preserved, making future manipulation and storage easier. Optimizing a freeze-drying cycle is of great importance since it aims at reducing process costs while increasing product quality of this time-and-energy-consuming process. Mathematical modeling comes as a tool to help a better understanding of the process variables behavior and consequently it helps optimization studies. Freeze-drying microscopy is a technique usually applied to determine critical temperatures of liquid formulations. It has been used in this work to determine the sublimation rates of a biological tissue freeze-drying. The sublimation rates were measured from the speed of the moving interface between the dried and the frozen layer under 21.33, 42.66 and 63.99 Pa. The studied variables were used in a theoretical model to simulate various temperature profiles of the freeze-drying process. Good agreement between the experimental and the simulated results was found.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000200003
Editor: | Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação: | 10.1590/S1984-82502012000200003
Formato: | text/html
Fonte: | Brazilian Journal of Pharmaceutical Sciences  v.48 n.2 2012
Fonte: | info:eu-repo/semantics/openAccess