Data/hora: 10/06/2024 12:18:38

Provedor de dados: | 60
País: | Brazil
Título: | Determination of moisture content in lyophilized mannitol through intact glass vials using NIR micro-spectrometers
Autores: | Muzzio,Cristian Rodrigo; Dini,Nicolás Gabriel; Simionato,Laura Daniela.
Data: | 2011-06-01
Ano: | 2011
Palavras-chave: | Near-infrared spectroscopy; Lyophilization; Multivariate analysis; Moisture content; Mannitol; Micro-spectrometer.
Resumo: | Determination of moisture content in lyophilized solids is fundamental to predict quality and stability of freeze-dried products, but conventional methods are time-consuming, invasive and destructive. The aim of this study was to develop and optimize a fast, inexpensive, noninvasive and nondestructive method for determination of moisture content in lyophilized mannitol, based on an NIR micro-spectrometer instead of a conventional NIR spectrometer. Measurements of lyophilized mannitol were performed through the bottom of rotating glass vials by means of a reflectance probe. The root mean standard error of prediction (RMSEP) and the correlation coefficient (R²pred), yielded by the pre-treatments and calibration method proposed, was 0.233% (w/w) and 0.994, respectively.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000200010
Editor: | Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação: | 10.1590/S1984-82502011000200010
Formato: | text/html
Fonte: | Brazilian Journal of Pharmaceutical Sciences  v.47 n.2 2011
Fonte: | info:eu-repo/semantics/openAccess