Data/hora: 06/06/2024 02:17:52

Provedor de dados: | 60
País: | Brazil
Título: | Pharmacokinetics of oleracimine in rats by ultra-high-performance liquid chromatography
Autores: | Qu,Gonglin; Xu,Liang; Zhang,Wenjie; Ying,Xixiang.
Data: | 2018-01-01
Ano: | 2018
Palavras-chave: | Portulaca oleracea L./Oleracimine; Ultra-High-Performance Liquid Chromatography/Rat plasma; Pharmacokinetics.
Resumo: | The novel alkaloid, oleracimine, presented remarkable anti-inflammatory bioactivity, and therefore, its pharmacokinetics was investigated in rat plasma after intravenous and oral administration by using a rapid ultra-high-performance liquid chromatography (UHPLC) method with UV detection at 270 nm. The analysis was performed on a shim-pack ODS column (75 mm×2 mm, 1.6 µm particle size, Shimadzu, Japan) column using isocratic elution with a mobile phase consisting of methanol-water (62:38, v/v) within 3 min. The results indicated that oleracimine was rapidly distributed with Tmax for 11.7 min after oral administration, which presented the double-peak phenomenon in the pharmacokinetic profile with a higher oral absolute bioavailability of 55.1% ± 7.83%.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400611
Editor: | Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação: | 10.1590/s2175-97902018000417242
Formato: | text/html
Fonte: | Brazilian Journal of Pharmaceutical Sciences  v.54 n.4 2018
Fonte: | info:eu-repo/semantics/openAccess