Data/hora: 17/06/2024 14:56:18

Provedor de dados: | 60
País: | Brazil
Título: | Evaluation of the antinociceptive and anti-inflammatory effects of the acetone extract from Anacardium occidentale L
Autores: | Vanderlinde,Frederico Argollo; Landim,Higor Frutuoso; Costa,Elson Alves; Galdino,Pablinny Moreira; Maciel,Maria Aparecida Medeiros; Anjos,Gineide Conceição dos; Malvar,David do Carmo; Côrtes,Wellington da Silva; Rocha,Fábio Fagundes da.
Data: | 2009-09-01
Ano: | 2009
Palavras-chave: | Anacardium occidentale L./analgesic activity; Anacardium occidentale L./anti-inflammatory activity; Anacardium occidentale L./antiedematogenic activity; Anacardiaceae; Cashew.
Resumo: | The stem bark of Anacardium occidentale L. (Anacardiaceae), commonly called cashew, is used in Brazilian traditional medicine for the treatment of gastric and inflammatory disorders. The present study was carried out to investigate the in vivo anti-inflammatory activities of the acetone extract (AE) of the stem bark of A. occidentale. We evaluated the pharmacological activities of this plant material through the analgesic, antiedematogenic and chemotaxic inhibitory effects produced by the AE. The oral administration (p.o.) of mice with the AE (0.1, 0.3 and 1.0 g/kg) or positive control indomethacin (10 mg/kg) inhibited acetic acid-induced writhing by 18.9, 35.9, 62.9 and 68.9%, respectively (ID50% = 530 mg/kg). The highest dose of the AE was able to inhibit croton oil-induced ear edema formation by 56.8% (indomethacin at 10 mg/kg, p.o. - 57.6% inhibition). When submitted to the carrageenan-induced peritonitis test, the AE (0.1, 0.3 and 1.0 g/kg, p.o.) impaired leukocyte migration into the peritoneal cavity by 24.8, 40.5 and 49.6%, respectively. The positive control, dexamethasone (2 mg/kg, s.c.), inhibited leukocyte migration by 66.9%. These results indicate the presence of anti-inflammatory and antinociceptive principles in the acetone extract of Anacardium occidentale, and reinforce the plant's potential therapeutic use against pain and inflammatory diseases.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000300008
Editor: | Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação: | 10.1590/S1984-82502009000300008
Formato: | text/html
Fonte: | Brazilian Journal of Pharmaceutical Sciences  v.45 n.3 2009
Fonte: | info:eu-repo/semantics/openAccess